Cervical Small Cell Neuroendocrine Carcinoma With Ectopic ACTH Secretion and Acute Pancreatitis

Abstract Ectopic Cushing syndrome from a primary carcinoma of the cervix is an exceedingly rare phenomenon. The objective this review to describe our clinical case and summarize characteristics, investigations, outcomes all published cases. We previously healthy 39-year-old woman presenting with abnormal uterine bleeding, leading diagnosis stage IIIC1 small cell neuroendocrine cervix, human papillomavirus-associated. She was treated neoadjuvant chemotherapy, radical hysterectomy, adjuvant pelvic radiation. Unfortunately, she developed progressive disease multifocal hepatic metastases lesions in para-aortic lymph nodes. Eighteen months after her initial diagnosis, presented severe acute pancreatitis died splenic artery pseudoaneurysm. A literature identified 10 cases ectopic ACTH secretion setting cervix. mean age presentation 40. majority (70%) occurred variant. In 80% patients, cushingoid features concomitantly or shortly discovery metastatic disease; included new-onset hypertension (30% patients), hyperglycemia (50%), hypokalemia (50%). All patients median survival 2.5 (range, 1-10 months) time syndrome. Carcinoma cause Nevertheless, it should be considered as source women, especially those gynecologic complaints. Despite surgical resection systemic therapy, prognosis poor.